The reason why some people infected with the coronavirus have no symptoms at all, while others are seriously ill is one of the biggest puzzles in the pandemic.
A study published in the scientific journal Nature of more than 2,200 patients admitted to intensive care facilities identified a specific gene that may be the reason.

That gene makes some people more susceptible to severe Covid-19 symptoms.

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These findings explain how the immune system is failing, so hopefully it will help identify new treatments.

This study will continue to be needed even though a vaccine is being developed, said Dr. Kenneth Baillie, a consultant medicine at the Royal Infirmary in Edinburgh, is leading the Genomicc project.

"Vaccines are supposed to reduce the number of Covid-19 cases drastically, but it is likely that doctors will still treat patients infected with the disease over the next few years around the world.

"So there is an urgent need to find new treatments," he said.

The 'angry' cells
Scientists looked at the DNA of patients in more than 200 intensive care units in British hospitals.

Scientists scan their genes, which contain instructions for every biological process - including how to fight viruses.

Their genomes are then compared with the DNA of healthy people to show genetic differences.

Some of the differences found were the first of which was a gene called TYK2.

"It's part of the system that makes your immune cells angrier and more inflamed," says Dr. Baillie.

But if the genes don't work, the immune response can become too rapid, putting patients at risk of developing lung inflammation.

Anti-inflammatory drugs already used for conditions such as rheumatoid arthritis target these biological mechanisms, including a drug called Baricitinib.

"That makes him a very reasonable candidate for a new treatment," said Dr. Baillie. "But of course, we need to do large-scale clinical trials to find out if this is true or not."

Too little interferon
Genetic differences were also found in the DPP9 gene, which plays a role in inflammation, and in a gene called OAS, which helps stop the virus from making copies of itself.

Variations in a gene called IFNAR2 were also identified in patients in intensive care.

IFNAR2 is linked to a powerful anti-viral molecule called interferon, which helps turn on the immune system as soon as an infection is detected.

Too little interferon production can cause the virus to multiply rapidly, leading to more severe symptoms.

Two other recent studies published in the journal Science also implicated the role of interferon in the case of Covid, through genetic mutations and autoimmune disorders that affect its production.

Prof Jean-Laurent Casanova, who conducted the research from The Rockefeller University in New York, said: "[Interferon] accounted for nearly 15% of critical Covid-19 cases reported internationally in the group of people we studied."

Interferon can be given as treatment, but World Health Organization clinical trials have concluded that it does not help very sick patients.

However, Prof. Casanova said when interferon was given important.

He explained: "I hope that if interferon is given in the first two, three, four days of infection, it will work, because basically interferon will provide molecules that [the patient] does not produce themselves."

'When things go wrong'

Dr Vanessa Sancho-Shimizu, a geneticist from Imperial College London, said that the genetic discovery provides unprecedented insights into the biology of the disease.

"This is really an example of precision medicine, allowing us to really identify when things go wrong in the patient's body," he told BBC News.

"The findings from this genetic study will help us identify specific molecular pathways that can be targeted for therapeutic interventions," he said.

But there are still some mysteries regarding this genome study.

The Genomicc study - and several others - have revealed a cluster of genes on chromosome 3 that are strongly associated with severe symptoms.

However, the biology underlying this is still not understood.

This study will involve more patients in the future.

Dr Baillie said: "We need everyone, but we are very interested in recruiting people from ethnic minority groups, which are a population with a large number of critical cases."

He added: "There is still a very urgent need to find new treatments for this disease and we have to make the right choices about which treatments to try next because we don't have time to make mistakes."​

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The public was surprised by the regulation that tourists to Bali must take the PCR test if they board an airplane . They feel the rules are too sudden because they have already bought tickets and hotels to Bali.
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"This is called a trap! The refund is also difficult. Departing must be PCR. Not going to Bali," wrote a detikers.

"Well, it's so complicated going to Bali," wrote Dicky.

"Desperate to want to restore Bali tourism but it is difficult for those who want to travel, what do you think ?," wrote another.

The provincial government of Bali today issued a Circular regarding mandatory PCR test rules for those using airplanes. Meanwhile, those who use land and sea trips are required to submit a negative rapid antigen test result.

Previously, the Coordinating Minister for Maritime Affairs and Investment Luhut Pandjaitan asked travelers to include the results of the H-2 swab or swab test before departure by plane.

"We ask that tourists who are boarding a plane to Bali must take the PCR H-2 test before their flight to Bali and require the H-2 rapid antigen test before land travel to Bali," said Luhut.

This rule comes into effect from December 18 to January 4 to reduce the transmission of the Corona virus in Bali.

"How come it's troublesome. The flight is all closed so we can cancel it. At this rate it will make everyone's loss. Now the flight with the hotel cancels, they can't refund," he said.

They considered it better not to need a test swab to board a plane to Bali . "The flight should also be sufficiently rapid antigen test, why PCR ?,"

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Jakarta -The police arrested S (40) after it was discovered that he had threatened to kill the Jakarta Police Chief, Inspector General Fadil Imran . The perpetrator threatened via messages spread on the WhatsApp application .

In the upload, the perpetrator posted a photo of Fadil complete with his official clothes. S narrates that Fadil is being hunted down.

"In a screenshot of the WhatsApp Kedai Kopi Indonesia group, the perpetrator posted a photo of the Jakarta Metro Police Chief complete with his official clothes and was given the words 'Looking for this person, assassins immediately contact mujafudfisabililah'," said Head of Public Relations of Polda Metro Kombes Yusri Yunus at the Metro Police Headquarters. Jaya, Jakarta, Monday (14/12/2020).

The perpetrator is known to be a trader. Based on the investigation, the perpetrators were members of several WhatsApp groups, including the names of 'Words of Facts' and 'Media Muslim Indonesia'.

According to Yusri, the perpetrators often uploaded and shouted hatred towards the TNI-Polri apparatus in the group. One of them was a message calling for Fadil to be removed from the position of Kapolda Metro Jaya and to remove General Idham Azis from the position of Chief of Police.

"So there are many sentences after we dig into this S cellphone and he is massive spreading it with provocative speech blaspheming the TNI-Polri . Including removing the Kapolda, removing the Pangdam, removing the Police Chief," explained Yusri.

Yusri added that since September 2020, perpetrator S had joined the two groups. Investigators are still investigating the suspect's role in the group.

In addition, the police are still investigating the motive of the perpetrator for making threats to the Jakarta Police Chief .

"We are still continuing to deepen who the perpetrator S was and why he dared to convey hate speech and threats to the security forces," explained Yusri.

For his actions, the perpetrator was charged under Article 28 paragraph 2 of the 2008 ITE Law with the threat of 6 years in prison.

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Jakarta -The joint team from Bareskrim Polri and Polda Metro Jaya (PMJ) will carry out a reconstruction of a firefight between the police and the FPI laskar on the Jakarta-Cikampek Km 50 toll road tonight. Reconstruction will be carried out in several locations.

"Yes, that's right, the gathering point at the Karawang Police is at 23.00 WIB," said Dirtipidum Bareskrim Polri Brigadier General Andi Rian when asked for confirmation on Sunday (13/12/2020).

Andi confirmed that the reconstruction of the shooting of the 6 FPI troops was open.

"Open, please. (Reconstruction was held in) several locations in Karawang Regency," said Andi.

Andi further revealed that the National Police invited a number of parties to attend the reconstruction of the shooting of the 6 FPI troops . One of the invited parties was the National Human Rights Commission.

"(The reconstruction was carried out by personnel) joint PMJ and Bareskrim. The reconstruction process was open by inviting Komnas HAM, KontraS, Amnesty International, and Kompolnas," said Andi.

As is known, the shooting incident of FPI's troops at the Jakarta-Cikampek Km 50 Toll occurred on Monday (7/12) in the morning. The police were said to be forced to take firm and measured action because the FPI paramilitary forces fought back.

"Members who were threatened with their safety because they were attacked then took firm and measured actions, so that the group suspected of being MRS followers, which numbered 10 people, died as many as 6 people," said the Head of Metro Jaya Police Inspector General Fadil Imran at his office, Jalan Jenderal Gatot Subroto, Jakarta, Monday (7/12).

"For the other 4 to run away," he added.

Meanwhile, based on the chronology from the FPI, six of Habib Rizieq's followers were in a metallic green Chevrolet car with police number B-2152-TBN trying to keep the stalker from the car that Habib Rizieq was in. The six followers were then attacked, kidnapped, and became victims of massacres.​

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Ciamis -A number of residents from various elements came to the Ciamis Police Headquarters, Jalan Jendral Sudirman, Sunday (13/12/2020). Their arrival was a form of protest against the detention of Habib Rizieq at Polda Metro Jaya.
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Previously they gathered at Ciamis Grand Mosque. Then they jointly staged a walk to the Ciamis Police. Even though it was pouring rain, the masses were still enthusiastic about taking action.

The crowd immediately entered the parking lot of the Ciamis Police and then gave speeches. In their speech they stated that they did not accept that high priest Habib Rizieq was wronged,

In addition, they also stated their readiness to replace Habib Rizieq in detention. Because his arrival also intended to surrender.

"We are ready to replace the high priest to be detained. If the high priest is hurt. We are ready to bleed. We only have one demand, release our Grand Imam," said one of the action coordinators, Wawan Malik Marwan.

Wawan also stated that he was ready to go to Jakarta if Habib Rizieq was not released immediately.

In addition to giving speeches, the participants also held a congregational presentation at the Ciamis Police Headquarters yard. Even though it was poured by heavy rain and with a makeshift base. The action ran safely and smoothly until it was finished at 16.15 WIB. They returned to their homes using several trucks that carried them.​

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Jakarta - Of the six suspects in the crowd in Petamburan , including Habib Rizieq Shihab , two suspects have not yet surrendered to Polda Metro Jaya. They are the General Chairperson of the FPI, Ahmad Shabri Lubis and the Commander of the Islamic Defenders Army (LPI) Maman Suryadi.
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"We also hope that the other two have not surrendered to surrender immediately," said Head of Public Relations of Polda Metro Jaya Kombes Yusri Yunus to reporters at the Jakarta Police Headquarters, Jakarta, Sunday (13/12/2020).

Yusri did not mention a deadline for surrender. However, he warned, if they do not turn themselves in immediately, the police will arrest them.

"As soon as possible. We will arrest him," he said.

It is known that three other suspects besides Habib Rizieq, namely Haris Ubaidillah as the committee chairman, Ali bin Alwi Alatas as the committee secretary, and Habib Idrus as the head of the event section, have surrendered to the Polda Metro Jaya.

"This morning at around 01.00 WIB, three of the five people surrendered themselves to Polda Metro Jaya," Yusri told reporters, Sunday (13/12).

"First on behalf of Haris Ubaidillah as committee chairman, then second on behalf of Idrus, third on behalf of Ali Alwi Alatas. The three men together with their lawyers came to Polda Metro Jaya and surrendered to Polda Metro," said Yusri.

To the three people, Polda Metro Jaya did not detain them. The reason is that their sentence is under 5 years.

Yusri Yunus explained, the three suspects were only suspected of Article 93 of Law Number 6 of 2018 concerning Health Quarantine with the threat of one year in prison. Yusri said, in the criminal law procedure, the threat of a criminal sentence of less than 5 years in prison cannot be detained.

"Article 93 is only a one year threat, it will not be detained," said Yusri.

The fate of the three people was different from Habib Rizieq Shihab who was a suspect and was arrested. Apart from the health quarantine article, Habib Rizieq was subject to the incitement article and against the officers.

The police continue to monitor the health condition of the leader of the Islamic Defenders Front (FPI) Habib Rizieq Shihab, who has now been detained at the Polda Metro Jaya remand center. Habib Rizieq is currently in good health.

"Until now, brother Rizieq Shihab, we told him last night we were detaining him at the Polda Metro Jaya Detention Center. His condition is healthy, we are still monitoring it," said Yusri.​

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Jakarta -For those of you who are hunters of natural phenomena , then don't miss this night, Sunday (13/12/2020) in vain. This is because the night sky will be beautiful with the presence of the Geminid meteor shower .

Geminid meteor showers are meteor showers whose radian point or point of origin for the emergence of these rocks is in the Gemini constellation. Well, the peak Geminid meteor shower occurs on December 13-14, 2020.

The National Institute of Aeronautics and Space ( Lapan ) revealed that the Geminid meteor shower can be witnessed from 20.00 WIB on the night of December 13 to 05.00 WIB the next day on December 14, 2020.

At least at the peak of the Geminid meteor shower , the intensity of the falling meteor ranges from 86 to 107 meteors per hour for the Indonesian region and the height of the radian point when the cultivation varies from 45 degrees, to be precise on Rote Island, to 65 degrees, on Weh Island.

Not only in Indonesia, Geminid meteor showers can also be witnessed around the world. The special thing is not only that, the United States Antarctic Agency (NASA), as quoted by VOA news, estimates that this meteor shower is decorated with up to 150 meteors per hour or the equivalent of two meteors per minute.

Meteor showers also occur during the new moon phase, meaning moonless nights, making it easier to see meteors as they pass through the sky.

"Over time, the intensity of Geminid meteor showers increased. That 50 years ago, Geminids had 15 or 16 meteors per hour. Now, the hourly rate has increased nearly 10 times in recent years," explains Bill Coke, Head of NASA's Meteorid Environment Office.

Observation of this geminid meteor shower will be successful, if the area where you live is free from cloudy clouds so that there is no light pollution caused by lighting, such as in cities.

This natural event is only one of the natural phenomena that took place in early December 2020. After the Geminid meteor shower , Lapan said, there will be the last sighting of an old crescent on December 14. On the same day there was a Total Solar Eclipse in South America, the next day there was the first appearance of a young crescent.

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Jakarta - Polda Metro Jaya confirmed that Habib Rizieq Shihab's status had now been arrested. Currently Habib Rizieq is still undergoing questioning at Polda Metro Jaya.
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"I have. Earlier a warrant for the arrest of the person was given," said Head of Public Relations of the Jakarta Metro Police, Kombes Yusri Yunus, when contacted by reporters, Saturday (12/12/2020).

Yusri also emphasized that Habib Rizieq did not come to answer the summons, but surrendered himself. Because, according to him, a summons was sent before Habib Rizieq became a suspect.

"I said earlier that there was no summons, but MRS surrendered," he said.

Yusri said the leader of the Islamic Defenders Front (FPI) mass organization was tested for antigen swabs before being examined. After the results of the antigen swab examination stated that Habib Rizieq was inactive, he was arrested.

"Earlier , we were swabbed first, then after the swab, we gave an arrest warrant and are now being investigated as a suspect," said Yusri.

Leader of the Islamic Defenders Front (FPI) Habib Rizieq Shihab arrived at Polda Metro Jaya this morning. Habib Rizieq admitted that he was ready to undergo examination.

"I can attend Polda Metro Jaya to take part in the examination in accordance with the applicable laws and regulations," said Habib Rizieq when he arrived at Polda Metro Jaya, Jalan Jenderal Sudirman, Central Jakarta, Saturday (12/12/2020).

There was no preparation made by Habib Rizieq for this examination. He admitted that he would answer all questions from investigators.

"There is no preparation, we answer, we finish. I thank God I'm always in good health," he said.

Habib Rizieq was reluctant to comment on the possibility that he would be detained after the investigation. But he admitted that he was ready to undergo an examination of the crowd.

"The important thing is for me to have a crowd check now," he said.​

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Jakarta -Some have asked President Joko Widodo (Jokowi) to be injected with the Corona vaccine first. This was disclosed by the Coordinating Minister for Maritime Affairs and Investment Luhut Binsar Pandjaitan. But he did not say who it was. Then, is Jokowi willing?

"The president yesterday said 'I will be injected with the people. So you can see, so don't get prejudiced, keep it away from prejudice. The government is once again giving the best to its people," he explained in a webinar held by Shopee, Saturday (12 / 12/2020).

The former Coordinating Minister for Political, Legal and Security Affairs continued to explain that Jokowi could also be injected with the Corona vaccine today , but he considered that this could lead to negative opinions.

"If the President wants to be injected first today, he can, but the President does not want to be told that he wants the president himself to go first or violate the rules. Everyone wants it to be made in an orderly manner," he said.

Luhut also said that Jokowi had asked to be vaccinated for the Corona virus first because some said the vaccine could cause illness.

"Some said it could hurt later, the president was given an injection," he added.

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Jakarta - FPI leader Habib Rizieq Shihab (HRS) visited Polda Metro Jaya after being named a suspect in the case of the crowd. However, the General Chairman of DPN Barikade-98, Benny Rhamdani, considered that Habib Rizieq's arrival was a trick to avoid being arrested.

"The plan for Rizieq Sihab's visit to Polda Metro Jaya must be interpreted as a form of trickery to avoid his arrest as the official statement issued by Polda Metro Jaya," said Benny in a written statement, Saturday (12/12/2020)

Benny said that Habib Rizieq's arrival at Polda Metro Jaya was not a form of obedience to the law. According to him, Habib Rizieq's disobedience to the law had been proven by his absence to fulfill the two summons of Polda Metro Jaya.

"The Criminal Code Article 224 paragraph (1) is very clear and firm if a person is absent or intentionally absent from the police summons, he will face a maximum penalty of 9 (nine) months in criminal cases or 6 (six) months in other cases," said Benny.

Benny said that Habib Rizieq was not an exemplary leader. Habib Rizieq called for a moral revolution, but in contrast to his behavior that ignored the law by failing to attend two summons by Polda Metro Jaya as a suspect in the crowd case in Petamburan, Central Jakarta.

"So that Barricade 98 gives support to Polda Metro Jaya to immediately detain Rizieq Sihab in accordance with the provisions of the applicable laws," he said.

"Barikade 98 also supports the Jakarta Police Chief's firm stance which states that no mass organization is above the state," he continued.

"The state should never give the opportunity to anyone, from any organization, to act arbitrarily and feel the best and can control this country by suppressing the rights and freedoms of other citizens," he said.

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